HIS-1004

Product Name:   Histones H3(F3),  may also contain H2b(F2B) and H2a(F2A2)

Description:

Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The histones are divided into fractions, with each fraction having a distinct amino acid composition and sequence. Histones are also classified by relatively high levels of lysine and arginine. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3).

Product Code:

Code Fractions Class MW Amount Price
HIS-1004
H3(F3)
Arginine rich
15,324
10 mg
$40.00
HIS-1014
H3(F3)
Arginine rich
15,324
25 mg
$80.00

References:

  1. Bradbury EM. “Histone Nomenclature in the Structure and Function of Chromatin.” (Fitzsimmins, D. W, and Walstenholme, G.E. W., eds.) CIBA Foundation symposium 28, American Elsevier, New York, 1975, pg 4.
  2. Elgin SCR, and Weinbrauh H. “Chromosomal Proteins and Chromatin Structure” in Annual Review of Biochemistry, (Smell, E. E., Boyer, P.D., Meister, A., and Richardson, C.C. eds. Annual Reviews,, Palo Alto, 1975, pg 725.
  3. Johns EW, and Butler JAV. “Further Fractionations of Histones from Calf Thymus.” Biochem. J ,Vol 82: 1962 , pg 15.

Specifications:

Certificate of Analysis: